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About the project

Patients

The registry contains records on all patients with tumours in the sellar region who were recorded in registries of cooperating endocrinology centres and who were diagnosed after 1 January 2000. Processing of personal data and recording of this data into the registry is in full compliance with the legislation in force (in particular, with the Act No. 101/2000 Coll.

As on 19 September 2012, the registry contained records on 592 patients in total:

  • 308 patients with acromegaly
  • 90 patients with Cushing's syndrome
  • 194 patients with prolactinoma

RESET is a clinical, fully non-interventional registry focused on the collection of clinical data with the aim of mapping the incidence, prevalence, morbidity and mortality in patients with sellar expansions.

RESET is registry of selected clinical centres which participate in the project on a voluntary basis. The project was initiated in 2008 and has been since coordinated by the General University Hospital in Prague.

The project is based on the collection of data for clearly defined clinical hypotheses. At the first stage, it is not aimed at the collection of representative epidemiological data; rather, it aims to monitor clinically well-defined groups of patients.

The RESET project has been prepared as a fully non-interventional registry which focuses on both retrospective and prospective collection of clinical data. Retrospective comparisons have been performed either within longitudinal time monitoring or on the "case-control" principle.

In clearly-defined groups of patients, the registry monitors the entire progression over time – from diagnostic data to therapy results with a subsequent long-time monitoring with annual updates ("follow-up"). Apart from followed-up and newly-diagnosed patients, basic data on previously-treated and already deceased patients are recorded into the registry as well. In this way, the registry will enable an effective assessment of mortality and survival parameters.

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